Endocrine Abstracts

Sports authorities prohibited the use of EPO in 1988 and at present any analogue or mimetic is also included in the list of prohibited substances from the World Anti-Doping Agency (WADA). The presentation will summarize the main analytical strategies developed to identify the presence of recombinant erythropoietin (EPO) administered as a doping agent.Indirect evidence is based on the analysis of blood parameters (haemoglobin, haematocrit, reticulocytes, ...

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Sex hormones act both as endocrine signals as well as local paracrine or autocrine factors in the nervous system. In addition to target to classical endocrine and reproductive brain areas, sex hormones and its metabolites affect learning and cognition and regulate the development and plasticity of brain regions that are not directly related to reproduction. Estrogen and progesterone exert neuroprotective effects in the central nervous system and may affect the onset and progre...

Our objective was to estimate the distribution of Spanish diabetic patients attending to individualized glycaemic targets recommended by the ADA/EASD consensus with and without considering hypoglycaemia risk. We conducted a cross-sectional study in a Spanish primary care setting between 2011 and 2012. A total of 5382 type 2 diabetic subjects under antihyperglycaemic treatment for at least 3 months prior to inclusion completed a study visit in which clinical data including age,...

Adverse events during gestation in rodents, results in an enhancement of immune function, including elevated levels of inflammatory cytokines in the brain. Liraglutide is a GLP-1 receptor agonists known to exert neuroprotective effects in brain. The aim of this study was to elucidate if liraglutide given to food restricted (FR) pregnant rats may prevent the deleterious effects of FR in the hippocampal inflammatory status of male and female pups at 21 days of age (D21). 20 Spra...

Endogenous as well as exogenous androgens and oestrogen have neuroprotective properties. Oestrogen is formed locally in neural tissue from precursor androgens. In the brain, the expression of aromatase, the enzyme that catalyses the conversion of androgens to oestrogen, is restricted, under normal circumstances, to specific neuronal populations involved in neuroendocrine control and in the modulation of reproductive or sexually dimorphic behaviours. However, the expression of ...

Introduction: Poems Syndrome is a rare multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma-proliferative disorder and skin changes, among other features. Literature describes endocrine abnormalities at least in 93% of patients with Poems Syndrome during the diagnosis as well as during the follow-up. The most common deficiencies ranked by their frequency are hypogonadism, hyperprolactinemia, hypothyroidism, abnormal glucose meta...

Introduction: We introduce a case involving the appearance of superior vena cava syndrome secondary to intrathoracic goitre. We discuss the diagnosis, prognosis and treatment applied to this pathology.Case report: A 67-year-old woman who presents respiratory distress, cough, and weight loss. After physical examination and a chest radiography showing a mass that occupied the upper and middle right lung lobes, a neoplasm is suspected and at first, palliati...

Objective: Relationship between pre-pregnancy BMI (PPBMI) in gestational diabetic (GD) patients, and age, country of origin, family history of type 2 diabetes mellitus (T2DM), GD history, and BMI after pregnancy.Methods: Transversal, descriptive study of 259 consecutive pregnant with confirmed DG. Analysis were based on Fisher’s exact test and Student’s t-test. A P<0.05 was significant (SPSS 19.0).Re...

The high sensitivity C-reactive protein (hs-CRP), mediator of atherosclerotic disease, is known to be a sensitive predictor of coronary heart disease in type 2 diabetes mellitus (T2DM).Aims: To evaluate the relationship of hs-CRP levels to metabolic syndrome (MS) and albuminuria in T2DM.Methods: Four hundred and eighty-eight T2DM subjects were recruited. Patients with hs-CRP ≥10 mg/l, creatinine ≥1.4 mg/dl, chronic infl...